Pyridoxine for the treatment of isoniazid-induced seizures in intentional ingestions: The experience of a national poison center

Intentional ingestion of INH is one of the causes of drug-induced seizures. Early recognition and specific treatment with pyridoxine can prevent mortality. Our series suggests that patients with large-dose intentional ingestions have a substantial risk of multiple seizures that can be treated successfully with 1 g of pyridoxine intravenously or 1 g of pyridoxine per gram of isoniazid ingestion. This antidote is safe and effective. Consideration can be given to administering pyridoxine prophylactically in some circumstances.