Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

Article ID	Journal	Published Year	Pages	File Type
10217870	Clinical Gastroenterology and Hepatology	2018	36 Pages	PDF

Abstract

The associations of BMI, smoking, and GERD symptoms with risks of EA and BE appear to varyÂ with SNPs at chromosomes 1, 2, and 15. Validation of these suggestive interactions isÂ warranted.

Keywords

EAF MAF GERD Esophageal adenocarcinoma genetic variants gastroesophageal reflux disease body mass index BMI Risk factors confidence interval minor allele frequency Barrett’s esophagus Esophagus Genome-wide association study GWAS Esophageal Neoplasm odds ratio Single nucleotide polymorphism SNP

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

Authors

Jing Dong, David M. Levine, Matthew F. Buas, Rui Zhang, Lynn Onstad, Rebecca C. Fitzgerald, Stomach and Oesophageal Cancer Study (SOCS) Consortium Stomach and Oesophageal Cancer Study (SOCS) Consortium, Douglas A. Corley, Nicholas J. Shaheen,