Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10218365 | Transfusion and Apheresis Science | 2018 | 5 Pages |
Abstract
A retrospective, observational study was performed of 112 patients who underwent autologous haematopoietic stem cell transplantation (ASCT) to determine the relationship between CD34+ stem cell dose and neutrophil engraftment. Importantly, a novel approach to more accurately calculate time to neutrophil engraftment was employed. The results demonstrated that a higher CD34+ stem cell dose was associated with faster neutrophil recovery (Pâ¯<â¯0.05). CD34+ stem cell dose using actual and ideal patient body weight were both equally predictive of neutrophil engraftment as were absolute and viable CD34+ measurements. The clinical implications for this relationship are limited with an increase in CD34+ stem cell dose by 1â¯Ãâ¯106/kg reducing the neutrophil engraftment time by only 3â¯h and 50â¯min. The median time to neutrophil recovery was 217â¯h (9 days and 1â¯h) and this relatively early engraftment time may be related to an early initiation of granulocyte colony-stimulating factor (G-CSF) on day +1 post-transplant. Female patients engrafted 17â¯h faster than their male counterparts on multi-variate analysis (Pâ¯<â¯0.05). Conditioning chemotherapy, bacteraemia, G-CSF dose/kg body weight and increasing age had no impact on time to neutrophil recovery.
Keywords
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Authors
Karthik Nath, Rachael Boles, Andrew McCutchan, Venkat Vangaveti, Andrew Birchley, Ian Irving,