Ubiquitin-proteasome signaling in lung injury

Article ID	Journal	Published Year	Pages	File Type
10219255	Translational Research	2018	22 Pages	PDF

Abstract

Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.

Keywords

RBR IKK SCF CLR TRAF2 ARDS Ripk1 TAK1 HECT NF-κB UBC13 HOIP PKCζ Cullin-RING ubiquitin ligase MET1 HOIL-1L TNFR-associated factor 2 N-terminal methionine GSK3 AMPK SUMO NEMO IFN-γ HIF-1α CFTR TLR cIAP ENaC IκB kinase Adenosine Triphosphate ATP Acute lung injury tight junctions Ali interleukin cellular Inhibitor of Apoptosis transforming growth factor-β-activated kinase 1 Sharpin Ring cystic fibrosis transmembrane conductance regulator Acute respiratory distress syndrome hypoxia-inducible factor 1α nuclear factor kappa-light-chain-enhancer of activated B cells LUBAC Toll like receptors NF-κB essential modulator Nedd adherens junctions epithelial sodium channel small ubiquitin-like modifier Interferon gamma glycogen synthase kinase-3 Ubiquitin