Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10219935 | European Urology | 2018 | 9 Pages |
Abstract
We studied the genomic characteristics of tumors from men diagnosed with low-risk prostate cancer. We found three main subtypes of prostate cancer with divergent tumor biology, similar to what has previously been found in women with breast cancer. In addition, we found that genomic risk scores were associated with worse pathology findings and prostate-specific antigen recurrence after surgery. These results suggest even greater genomic diversity among low-risk patients than has previously been documented with more limited signatures.
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Authors
Matthew R. Cooperberg, Nicholas Erho, June M. Chan, Felix Y. Feng, Nick Fishbane, Shuang G. Zhao, Jeffry P. Simko, Janet E. Cowan, Jonathan Lehrer, Mohammed Alshalalfa, Tyler Kolisnik, Jijumon Chelliserry, Jennifer Margrave, Maria Aranes,