Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10220210 | Gynecologic Oncology | 2018 | 8 Pages |
Abstract
Systemic inflammation and TILs are early determinants of OS in HGSOC. Other variables such as the quality of debulking surgery and PDL1 also improve survival of patients. Regarding TIL sub-populations, intraepithelial CD4+ cells are associated to an increase in both PFS and OS. We also confirmed previous reports that demonstrate intraepithelial CD8+ cells correlate with an increase on PFS in ovarian cancer. A combined score using systemic inflammation and TILs may be of prognostic value for HGSOC patients.
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Authors
Mauricio P. Pinto, Carlos Balmaceda, Maria L. Bravo, Sumie Kato, Alejandra Villarroel, Gareth I. Owen, Juan Carlos Roa, Mauricio A. Cuello, Carolina Ibañez,