Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10220522 | Journal of Thoracic Oncology | 2018 | 9 Pages |
Abstract
In the largest series of EGFRex20ins NSCLC, diverse EGFRex20ins were detected in 12% of EGFR-mutant NSCLC, a higher frequency than previously reported in smaller single-institution studies. Clinical outcomes showed lack of response to EGFR TKIs. Tumor mutational burden was low, consistent with non-smoking associated NSCLC. Comprehensive sequencing revealed increased proportion and wide variety of EGFRex20ins, representing a population of patients significant enough for focused efforts on effective interventions.
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Authors
Jonathan W. MD, MS, David R. MD, Garrett M. PhD, Russell BS, Nir MD, PhD, Jose A. MD, Grace K. MD, Sai-Hong Ignatius MD, PhD, Philip J. PhD, John D. PhD, Primo N. MD, Rebekah A. BA, Jeffrey S. MD, Vincent A. MD, Siraj M. MD, PhD, Philip C. PhD,