| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10220526 | Journal of Thoracic Oncology | 2018 | 11 Pages |
Abstract
The 5T4 antigen is expressed in mesothelioma and 5T4-based ADCs are internalized in lysosomes. Two of three ADCs were capable of killing the mesothelioma cells; the third ADC required additional lysosomal neutralization for its effect. 5T4-based ADCs would be a selective strategy for the treatment of mesothelioma.
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Authors
Laurel M. MSc, Kim PhD, Vincent PhD, Ruud PhD, Dennis BSc, Wilbert PhD, Jacques PhD, Paul MD, PhD,