Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10221735 | The Spine Journal | 2018 | 33 Pages |
Abstract
Systemic opioids led to an inferior quality fusion mass with delay in maturation and remodeling at 6 weeks in this rabbit spinal fusion model. These preliminary results lay the foundation for further research to investigate underlying cellular mechanisms, the temporal fusion process, and the dose-duration relationship of opioids responsible for our findings.
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Authors
Nikhil MD, Khaled BS, Jeffrey M. PhD, Karen C. PhD, Frank M. MD, Safdar N. MD,