Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10223158 | Neuroscience | 2018 | 19 Pages |
Abstract
This study aimed to investigate the relation of GABA and glutamate levels in the posterior insula and mechanical pain sensitivity in healthy subjects. Nineteen healthy female individuals underwent single voxel magnetic resonance spectroscopy (MRS) at 3â¯T. Metabolites were measured in the right posterior insula using MEGA-PRESS spectral editing. Mechanical pain sensitivity was experimentally assessed with pinprick stimuli on a numeric rating scale. Ratings of perceived intensity of 256â¯mN and 512â¯mN pinprick stimuli were negatively correlated with GABA levels and positively with glutamate levels in the posterior insula. Pinprick pain ratings were also positively correlated with the glutamate/GABA ratio. No significant correlation for pinprick stimuli of lower forces than 256â¯mN was observed. The results of our study support the hypothesis that excitatory and inhibitory neurotransmitter levels and/or the ratio of glutamate/GABA levels in the posterior insula are related to individual differences in pain sensitivity. These results are in line with chronic pain studies, where elevated glutamate/GABA ratios in the insular cortex of patients with chronic pain syndromes were observed.
Keywords
GLNHLSVDTCrMRSMP-RAGESPSSFWHMMEGA-PRESSCRLBGlxγ-aminobutyric acidPainecho timeRepetition timemagnetic resonance spectroscopySpectroscopyfull width at half maximumGray matterwhite matterCerebrospinal fluidCSFmagnetization prepared rapid gradient echopinprickPosterior insulatotal creatineGABAGluglutamateglutamine
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Authors
Margot Thiaucourt, Polina Shabes, Natalie Schloss, Markus Sack, Ulf Baumgärtner, Christian Schmahl, Gabriele Ende,