Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10223160 | Neuroscience | 2018 | 46 Pages |
Abstract
The present study evaluates the possible antinociceptive effect of chromosphere transplants in rats injected with 6-hydroxydopamine (6-OHDA), a model of Parkinson's disease. Male adult Wistar rats received 40 μg/0.5 μl of 6-OHDA or 0.5 μl of vehicle into the left substantia nigra (SNc). Rats were evaluated for mechanical allodynia, cold allodynia, thermal hyperalgesia and formalin. Rats with altered nociceptive threshold were transplanted with chromospheres. After transplant, rats were evaluated every week. Our results confirm that 6-OHDA injection into rat's SNc reduces mechanical, thermal, and chemical thresholds. Interestingly, chromospheres' transplant reverted 6-OHDA-induced allodynia and hyperalgesia. The antinociceptive effect induced by chromospheres was dopamine D2- and opioid-receptor dependent since sulpiride or naltrexone reverted its effect.
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Neuroscience
Neuroscience (General)
Authors
Alejandra Gómez-Paz, René Drucker-ColÃn, Diana Milán-Aldaco, Marcela Palomero-Rivero, Mónica Ambriz-Tututi,