| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10224691 | British Journal of Anaesthesia | 2018 | 8 Pages |
Abstract
FIX derived from PCC strongly enhances tissue factor-triggered thrombin generation in the presence of elevated FVIII activity. Haemodilution further enhances procoagulant effects of FIX and FVIII by slowing down inhibition of procoagulant enzymes. Dosing of PCC per prothrombin time may underestimate PCC's procoagulant potential because it does not account for intrinsic tenase or antithrombin activity.
Related Topics
Health Sciences
Medicine and Dentistry
Anesthesiology and Pain Medicine
Authors
S. Hasan, E. Abuelkasem, B. Williams, R. Henderson, M.A. Mazzeffi, K.A. Tanaka,