Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10244621 | Journal of Catalysis | 2005 | 4 Pages |
Abstract
The use of one equivalent of benzylamine increased the enantioselectivity in the heterogeneous catalytic hydrogenation of α,β-unsaturated carboxylic acids over cinchonidine-modified 5% Pd/Al2O3 catalyst. The beneficial effect of the amine additive was dependent on substrate structure. The highest effect, a more than sixfold increase in the enantiomeric excess, was obtained in the hydrogenation of itaconic acid. This is the first report on the enantioselective hydrogenation of a prochiral α,β-unsaturated dicarboxylic acid over a supported heterogeneous metal catalyst.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
György SzöllÅsi, Taka-aki Hanaoka, Shu-ichi Niwa, Fujio Mizukami, Mihály Bartók,