Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10255271 | Pathology | 2005 | 4 Pages |
Abstract
The birth prevalences of heterozygosity and homozygosity for the four thrombophilic polymorphisms were: factor V Leiden 9.5% and 0.7%, prothrombin gene 4.1% and 0.2%, MTHFR C677T 37.3% and 12.4%, and MTHFR A1298C 38.3% and 11.8%, respectively. Compound heterozygosity for MTHFR C677T and A1298C was seen in 16.6% of the population. Overall, 64.2% and 24.5% of the population studied were homozygous and heterozygous, respectively, for at least one of the four polymorphisms studied. Conclusion: Inherited thrombophilic polymorphisms are common in the Caucasian Australian population. Knowledge of the background prevalence of these polymorphisms will allow further study of their associations in future disease research.
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Authors
South Australian Cerebral Palsy Research Group South Australian Cerebral Palsy Research Group, Catherine S. Gibson, Alastair H. MacLennan, Zbigniew Rudzki, William M. Hague, Eric A. Haan, Phillipa Sharpe, Kevin Priest, Annabelle Chan, Gustaaf A. Dekker,