A reduced order rate based model for distillation in packed columns: Dynamic simulation and the differentiation index problem

► We introduce a reduced order rate based model for distillation in packed columns. ► It is shown that despite the large-scale model, structure can be efficiently exploited. ► The high differentiation index problem is studied. ► A procedure based on structural analysis of model Jacobian is proposed for index reduction. ► Model dynamic simulation and parameter sensitivity analysis for the proposed model is presented.