Article ID Journal Published Year Pages File Type
10262718 Chemical Engineering Science 2005 11 Pages PDF
Abstract
Continuous separation of enantiomer (RSR)-nadolol from its racemate (which is a ternary mixture in the chromatographic system of this study) in both 2-raffinate and 2-extract configuration of five-zone SMB was studied. Same experimental setup was applied to both configurations by modifying SMB controlling program accordingly. Separation performances of the five-zone SMB were investigated for both 2-raffinate and 2-extract configurations and same safety factors were applied to investigate the effect of m3-m2 (or m4-m3) on the separation performance systematically. The desired enantiomer of nadolol can be produced with a high purity and yield in 2-raffinate configuration compared with that in 2-extract configuration.
Related Topics
Physical Sciences and Engineering Chemical Engineering Chemical Engineering (General)
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