Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10265111 | Comptes Rendus Chimie | 2016 | 9 Pages |
Abstract
[1,4]-additions of various nucleophiles such as lithiated carbamates, alkoxides or ester enolates onto enantiopure alkylidene bis-sulfoxides proceed with high diastereoselectivity. The oxidation of the resulting carbanions with iron(III) salts induces the radical cyclizations onto alkenes with a high diastereoselectivity leading to enantiopure carbo- or heterocycles. Moreover, allylic radicals have been generated by deprotonation or [1,6]-conjugate addition from alkylidene bis-sulfoxides followed by oxidation.
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Chemical Engineering
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Authors
Guillaume Vincent, Saloua Cheli, Rocio Martinez Mallorquin, Adi Abramovitch, Sophie Beauvière, Catherine Gomez, Franck Brebion, Ilan Marek, Max Malacria, Jean Philippe Goddard, Louis Fensterbank,