Quantitative structure-property relationships of new benzoxazines and their electrooxidation as a model of metabolic degradation

The study of electrochemical oxidation of these compounds as a model of their possible metabolic degradation was performed. It was possible to propose general scheme of electrochemical oxidation of sulfur containing benzoxazine derivatives. From the metabolic point of view, desulfuration is the corresponding process to this pathway. As these derivatives were not examined in vivo, obtained results represent very beneficial clues, and, moreover, proposed scheme could serve as a support for the explanation of strong antimycobacterial activity of sulfur containing benzoxazines.