Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

A novel granulated pellets technique was adopted to prepare granulated pellet-containing tablets (GPCT), as shown in the following illustration. The superiority of GPCT was mainly due to the excipient layer, which was laid over the coated pellet and could greatly influence the stability of GPCT in storage.