Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10298623 | European Neuropsychopharmacology | 2015 | 21 Pages |
Abstract
In total, 1528 patient-months were compiled (70 with an EMS). Univariate analyses demonstrated that the rate of patient-month to EMS increased gradually with AWAC (p<0.001), from 0.9% for AWAC=0 to 9.4% for AWAC >35. There was also a significant gradual risk for EMS associated with DDB (<0.001). Multivariate analysis demonstrated a significant interaction between DDB and AWAC on EMS risk (p=0.047). Each 20Â mg/d increase in DDB was associated with an OR of EMS in AWAC >35 of 1.22 (95%CI, 1.08-1.38) versus 1.11 (95%CI, 0.96-1.29) in AWAC=1-35, and 0.95 (95%CI, 0.76-1.19) in AWAC=0. The level of sedation observed in patients using baclofen for alcohol dependence appears to directly depend on the immediate doses of both the baclofen and the alcohol.
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Authors
Benjamin Rolland, Julien Labreuche, Alain Duhamel, Sylvie Deheul, Sophie Gautier, Marine Auffret, Baptiste Pignon, Thomas Valin, Régis Bordet, Olivier Cottencin,