Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10298728 | European Neuropsychopharmacology | 2011 | 8 Pages |
Abstract
Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and negatively impacts on disease outcome. Using an animal model that mimics features of AN including food-restriction induced hyperlocomotion, we demonstrate that central leptin injections in the lateral ventricle and local injections of leptin into the ventral tegmental area (VTA) suppress running wheel activity. The results support that falling levels of leptin, that accompany caloric restriction, result in increased activity levels because of decreased leptin signaling in the VTA, part of the mesolimbic reward system.
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Authors
Linda A.W. Verhagen, Mieneke C.M. Luijendijk, Roger A.H. Adan,