Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10300465 | European Neuropsychopharmacology | 2005 | 4 Pages |
Abstract
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]β-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
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Authors
Oliver Pogarell, Gabriele Poepperl, Christoph Mulert, Christine Hamann, Nikolai Sadowsky, Michael Riedel, Hans-Juergen Moeller, Ulrich Hegerl, Klaus Tatsch,