| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10300469 | European Neuropsychopharmacology | 2005 | 11 Pages |
Abstract
Thus, sub-chronic agomelatine treatment or a single agomelatine injection reduced a state of anxiety and passivity caused by asocial defeat. The defeat-induced behavioural changes do not depend on the SCN but agomelatine showed its anxiolytic action only in sham-lesioned animals, which indicates that the anxiolytic-like action of agomelatine requires the integrity of the SCN. Mechanisms sustaining this activity are discussed.
Keywords
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Jolanda Tuma, Jan H. Strubbe, Elisabeth Mocaër, Jaap M. Koolhaas,