Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young female rats

► G-15 dose-dependently impairs acquisition of a T-maze task in intact rats and in ovariectomized rats treated with estradiol. ► G-15 reduces the rate of acquisition by increasing the predisposition to adopt a persistent turn. ► No G-15 effects were observed in intact rats tested on an operant discrimination/reversal learning task.