| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10301142 | Hormones and Behavior | 2011 | 9 Pages |
Abstract
⺠Intra-dPAG CRF produces antinociception and increases anxiety in mice exposed to the elevated plus-maze (EPM). ⺠Anxiogenic and antinociceptive effects produced by intra-dPAG CRF are prevented by local infusion of CRF1 receptor antagonist. ⺠Blockade of CRF2 receptors in the dPAG does not change the anxiogenic and antinociceptive effects produced by CRF injection. ⺠dPAG CRF1 (but not CRF2) receptors play an important role in the anxiety and antinociception induced by the local CRF.
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Authors
Tarciso Tadeu Miguel, Ricardo Luiz Nunes-de-Souza,