Clinical features and drug induced side effects in early versus late antidepressant responders

In the STAR*D late responders reported higher levels of antidepressant induced side effects, especially difficulty in sleeping (p = 5.68e-13), with a non significant trend in the same direction in the Italian sample (p = 0.09). The identification of late versus early antidepressant responders at the beginning of the treatment may be useful to guide therapeutic choices in clinical settings.