| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10305153 | Psychiatry Research | 2005 | 4 Pages |
Abstract
We studied cytokine production in 15 patients with chronic fatigue syndrome (CFS) and 23 controls. CFS patients' peripheral blood mononuclear cells were cultured with lipopolysaccharide or phytohemagglutinin. Enzymatic immunoassay indicated cytokine concentration in culture supernatants. CFS patients showed significantly lower mRNA levels and transforming growth factor-beta1 (TGF-β1) production. Cytokine dysregulation affects CFS pathogenesis. TGF-β1 may aid treatment because it affects CFS inflammatory characteristics.
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Authors
Akemi Tomoda, Takako Joudoi, El-Mezayen Rabab, Tomoaki Matsumoto, T.H. Park, Teruhisa Miike,