Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10305736 | Psychiatry Research: Neuroimaging | 2005 | 5 Pages |
Abstract
A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was persistent after intrathecal interferon-α treatment. Spectroscopy pointing to ongoing inflammation, gliosis, and possible membrane turnover was more sensitive than imaging in detecting widespread pathology within the white matter.
Keywords
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Nikolaus Michael, Andreas Erfurth, Peter Lüdemann, Gerhard Schuierer, Harald E. Möller,