Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10306316 | Psychoneuroendocrinology | 2012 | 13 Pages |
Abstract
In univariate analyses, we observed significantly decreased RNA integrity (RIN) score (P = 0.04), and reduced expression of glucocorticoid receptor-regulated genes (Ps < 0.05) in whole saliva RNA from individuals exposed to chronic stressors, as compared to those with no exposure. In those exposed, we observed significantly decreased BMI (P < 0.001), increased ever-smoking and increased lifetime alcohol abuse or dependence (P â¤Â 0.03), and a reduction of cortisol release. In post hoc multivariate analyses including clinical and biospecimen-derived variables, we consistently observed significantly decreased expression of IL8 (Ps < 0.05) in individuals exposed, with no significant association to RIN score. Alcohol use disorders, tobacco use, a reduced acute stress response and decreased salivary IL8 gene expression characterize emerging adults chronically exposed to severe and threatening psychosocial stressors.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Andrew W. Bergen, Aditi Mallick, Denise Nishita, Xin Wei, Martha Michel, Aaron Wacholder, Sean P. David, Gary E. Swan, Mark W. Reid, Anne Simons, Judy A. Andrews,