| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10306540 | Psychoneuroendocrinology | 2009 | 6 Pages |
Abstract
Results indicated that CMS followed by VEH induced widespread decreases in TR-α1 mRNA in brain. In contrast, CMS-exposed rats receiving IMI for the last 2 weeks prior to sacrifice showed full recovery of sucrose preference. Furthermore, brain TR-α1 mRNA levels in these animals were similar to those of non-stressed controls receiving either SAL or IMI. These results reveal that TR-α1 mRNA brain levels are very sensitive to CMS effects. The reversal of both anhedonic and TR-α1 effects of CMS by IMI suggests that TR-α1 may play a role both in stress-induced depressive symptoms and in their reversal by antidepressant interventions.
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Authors
Edward J. Stein, Nylson G. da Silveira Filho, Danilo C. Machado, Débora C. Hipólide, Karen Barlow, José N. Nobrega,