Hypertension and depressed symptomatology: A cluster related to the activation of the renin-angiotensin-aldosterone system (RAAS). Findings from population based KORA F4 study

The finding of highly significantly increased aldosterone levels and increased renin levels in individuals suffering both, depressed symptomatology and hypertension provides further evidence for the involvement of the RAAS in the pathogenesis of depressed symptomatology. These findings have important implications for future research concerning the pathophysiological pathways that link depression and cardiovascular disease.