Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10308627 | Seizure | 2005 | 4 Pages |
Abstract
We identified 46 patients with a history of partial seizures, with and without secondarily generalization, who received levetiracetam (LEV) (Keppra®) monotherapy. Patients began LEV either as first line therapy (n = 11) or were converted to LEV monotherapy (n = 35) after failing prior antiepileptic medications (AEDs). Patients were followed up to 12 months after LEV started. The majority of these patients were able to continue on LEV and a small number of patients discontinued LEV secondary to lack of efficacy. One third of the non-seizure free group at 6 months of follow-up had worse seizure control at 12 months and two thirds had the same or better seizure control. Our 1-year follow-up data of LEV as monotherapy suggests that LEV can be effective and well tolerated in adults with either new or difficult to control epilepsy. A prospective, large, long-term double-blind study is needed to confirm this finding.
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Authors
Taoufik M. Alsaadi, Alan Shatzel, Anna Vinter Marquez, Julie Jorgensen, Sarah Farias,