Article ID Journal Published Year Pages File Type
10337283 Journal of Molecular Graphics and Modelling 2005 7 Pages PDF
Abstract
RNA polymerase (RNAP) is the central enzyme of transcription and requires interaction with transcription factors in vivo for correct processivity. Both the transcription initiation complex and the ternary elongation complex are stabilised by and require protein-protein interactions between the various components involved. These interactions may form the basis for rational design of small peptide mimics of one or more proteins involved in order to inhibit protein-protein interactions and thus transcription. Here, we present homology models of the model Gram positive organism Bacillus subtilis RNA polymerase in the core and holoenzyme forms. Interactions between RNA polymerase and the transcription factor σA were investigated in order to design peptide mimics of the major interactions.
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
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