| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10337814 | Journal of Molecular Graphics and Modelling | 2011 | 8 Pages |
Abstract
⺠Exploring effect of CpG methylation on DNA-binding transcription factor will be useful. ⺠The binding-induced structural changes upon the DNA-PITX2 complexation are further encouraged by CpG methylation. ⺠Recognizing sites by the Lys50 appear to have distinct mobility due to CpG methylation. ⺠The methylated CpG that is close to the binding region between PITX2 and the DNA major groove can promote the DNA-protein association. ⺠CpG methylation can reduce the unfavorable entropic effects and increase the binding free energy of PITX2-DNA association.
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Authors
Si-Ya Yang, Xiao-Li Yang, Li-Feng Yao, Hai-Bo Wang, Chen-Ke Sun,