Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10374815 | Colloids and Surfaces B: Biointerfaces | 2011 | 5 Pages |
Abstract
â¶ We have prepared the compound nanoparticles of chitosan and cyclodextrin loading with hydrophilic and hydrophobic drug simultaneously. â¶ Methotrexate and calcium folinate are selected as the mode drugs. â¶ We examine the loading capacity, size, zeta potential and surface morphology of the nanoparticles. â¶ The chitosan/cyclodextrin nanoparticles exhibit stronger sustained release effect comparing to chitosan nanoparticles and the release mechanism followed a non-Fickian type behavior.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Ji Jingou, Hao Shilei, Liu Weiqi, Wu Danjun, Wang Tengfei, Xu Yi,