Article ID Journal Published Year Pages File Type
10374828 Colloids and Surfaces B: Biointerfaces 2011 5 Pages PDF
Abstract
▶ A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated. ▶ SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. ▶ SA-Se-NPs induced dose-dependent apoptosis in HeLa cells through activation of caspase-3 and subsequent cleavage of PARP.
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Related Topics
Physical Sciences and Engineering Chemical Engineering Colloid and Surface Chemistry
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Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles
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