Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
103852 | Legal Medicine | 2010 | 5 Pages |
Abstract
Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC–MS and determined by HPLC-DAD in the samples from a postmortem case. The femoral blood concentrations of clobazam and norclobazam were 0.72 and 36 μg/mL, respectively. The concentration of the active norclobazam was very high. The sum of both clobazam and norclobazam blood concentration (36.72 μg/mL) was clearly toxic, but was not necessarily fatal. Other associated drugs concentrations were within their therapeutic ranges. Interactions due to drug association were discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Phak-Rop Pos Pok, Michel Mauras, Marie-Noëlle De Saint Léger, Erika Kuhlmann, Catherine Charpenel-Durat, Claudie Navarette, Marie-Laure Duval, Pierre De Meo,