Recovery of erythromycin from fermentation broth by adsorption onto neutral and ion-exchange resins

The thermodynamic parameters such as ΔHads, ΔSads and ΔGads were calculated to predict the nature of adsorption. The positive value of enthalpy (6 kJ/mol) suggest that the original salt in the resin is bound strongly, while the positive value of entropy (54 J/mol K) means that liberation of the salt into the solution is entropically favorable, and the favorable entropy drives the overall process, with a free energy of adsorption of −10 kJ/mol.