| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10395643 | Bioresource Technology | 2010 | 5 Pages |
Abstract
In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.
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Process Chemistry and Technology
Authors
Hyun Yong Shin, Jin Young Lee, You Ree Jung, Seung Wook Kim,