| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10429228 | Tsinghua Science & Technology | 2005 | 5 Pages |
Abstract
Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer's disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.
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Authors
Li (æå¿ä¸), Wang (çèè), Zhou (å¨è³è³), Gao (é« é), Peng (å½é«å), Xu (许åæ¦), Chen (éæå
),