Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10429354 | Biosensors and Bioelectronics | 2012 | 7 Pages |
Abstract
⺠We established a novel combination of fluorescent protein-based biosensors for dual-parameter ratiometric imaging in single living cells. ⺠Using this approach, we achieved simultaneous imaging of Src/Ca2+ signaling and GSH redox potential in single living cells, which was previously unattainable. ⺠Furthermore, we provided evidence that EGF-induced Src signaling was negatively regulated by H2O2 via its effect on GSH-based redox system.
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Chemistry
Analytical Chemistry
Authors
Ting Su, Zhihong Zhang, Qingming Luo,