| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10429379 | Biosensors and Bioelectronics | 2012 | 7 Pages |
Abstract
⺠We develop a DNA methylation assay based on single base extension reaction and SERS. ⺠Single base extension reaction offers high selectivity and specificity. ⺠Gold nanoparticle-induced SERS enhancement offers high sensitivity. ⺠This DNA methylation assay can achieve a detection limit of 3 pM. ⺠It can even distinguish as low as 1% methylation level from the mixtures.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Juan Hu, Chun-yang Zhang,