Article ID Journal Published Year Pages File Type
10429465 Biosensors and Bioelectronics 2011 8 Pages PDF
Abstract
► We have measured interaction strength between the transcription factor NF-κB and its DNA target (ODN), by AFM. ► Using different kind of modified tips we characterized LNA modified ODNs interaction strength. ► Force measurement was proper to test drugs, able to inhibit NF-κB and potentially suitable to modulate its activity.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Binding force measurement of NF-κB-ODNs interaction: An AFM based decoy and drug testing tool
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