Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10429477 | Biosensors and Bioelectronics | 2011 | 4 Pages |
Abstract
Nanoscale Field Effect Transistors have emerged as a promising technology for ultrasensitive, unlabeled diagnostic applications. However, their use as quantitative sensors has been problematic because of the need for individual sensor calibration. In this work we demonstrate an internal calibration scheme for multiplexed nanoribbon field effect sensors by utilizing the initial current rates rather than end point detection. A linear response is observed consistent with initial binding kinetics. Moreover, we are able to show that top-down fabrication techniques yield reproducible device results with minimal fluctuations, enabling internal calibration.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Aleksandar Vacic, Jason M. Criscione, Eric Stern, Nitin K. Rajan, Tarek Fahmy, Mark A. Reed,