Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10430220 | Biosensors and Bioelectronics | 2005 | 11 Pages |
Abstract
Nucleic acids and proteins have been printed in microarray format on slides with a gold film in place using gold-sulphur interactive chemistry. Hybridization of nucleic acids for complementary and mismatched configurations shows consistent and reproducible values of work function. Differentiation of single internal mismatches is demonstrated. Protein concentration and formation of antibody-antigen pairs can be visualized and examined with high sensitivity and good inter-spot reproducibility.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Michael Thompson, Larisa-Emilia Cheran, Mingquan Zhang, Melissa Chacko, Hong Huo, Saman Sadeghi,