Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10431147 | Journal of Biomechanics | 2016 | 5 Pages |
Abstract
This study demonstrates that mesenchymal stem cells from aged animals have an altered membrane environment, are more vulnerable to the pro-apoptotic effects of 10% tensile strain and less responsive to the pro-osteogenic effects of 2.5% tensile strain. Thus, it is essential to consider how aged cells respond to mechanical stimuli in order to identify optimal mechanical priming strategies that minimise cell loss, particularly if this approach is to be applied to an aged population.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Katey McKayed, Patrick J. Prendergast, Veronica A. Campbell,