Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10431651 | Journal of Biomechanics | 2015 | 6 Pages |
Abstract
This work presents a methodology for the in vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the deformation of human corneas due to non-contact tonometry, and an iterative search controlled by a genetic heuristic was used to estimate the elastic parameters that most closely approximates the simulated deformation to the real one. The results from a synthetic experiment showed that these parameters can be estimated with an error of about 5%. The results of 24 in vivo corneas showed an overlap of about 90% between simulation and real deformed cornea and a modified Hausdorff distance of 25 μm, which indicates the great accuracy of the proposed methodology.
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Authors
M.A. Lago, M.J. Rupérez, F. MartÃnez-MartÃnez, C. Monserrat, E. Larra, J.L. Güell, C. Peris-MartÃnez,