What have we learned from finite element model studies of lumbar intervertebral discs in the past four decades?

The disc overall response as well as the relative role of its constituents are markedly influenced by loading rate, magnitude, combinations/preloads and posture. The nucleus fluid content and pressurizing capacity affect the disc compliance, annulus strains and failure sites/modes. Biodynamics of the disc is affected by not only the excitation characteristics but also preloads, existing mass and nucleus condition. The role of fluid pressurization and collagen fiber stiffening diminish with time during diurnal loading. The endplates permeability influences the time-dependent response of the disc in both loaded and unloaded recovery phases. The transport of solutes is substantially influenced by the disc size, tissue diffusivity and endplates permeability.