Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10432701 | Journal of Biomechanics | 2012 | 8 Pages |
Abstract
Recent studies have demonstrated that actin filaments are not crucial for the short-term stability of tubular membrane protrusions originating from the cell surface. It has also been demonstrated that prominin nanodomains and curvature inducing I-BAR proteins could account for the stability of the membrane protrusion. Here we constructed an axisymmetric model of a membrane protrusion that excludes actin filaments in order to investigate the contributions of prominin nanodomains (rafts) and I-BAR proteins to the membrane protrusion stability. It was demonstrated that prominin nanodomains and I-BAR proteins can stabilize the membrane protrusion only over a specific range of spontaneous curvature. On the other hand, high spontaneous curvature and/or high density of I-BAR proteins could lead to system instability and to non-uniform contraction in the radial direction of the membrane protrusion. In agreement with previous studies, it was also shown that the isotropic bending energy of lipids is not sufficient to explain the stability of the observed tubular membrane protrusion without actin filaments.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Doron Kabaso, Nataliya Bobrovska, Wojciech Góźdź, Nir Gov, Veronika Kralj-IgliÄ, Peter VeraniÄ, AleÅ¡ IgliÄ,