Article ID Journal Published Year Pages File Type
10432899 Journal of Biomechanics 2011 5 Pages PDF
Abstract
Traditional magnetic resonance elastography (MRE) applies small amplitude vibration to tissues. Thus currently MRE measures only the small deformation behaviour of tissues. MRE has the potential to estimate the strain-varying shear modulus of soft tissues, if applied at different static strains, which may allow prediction of the large-strain behaviour of tissues. This study uses MRE of bovine liver specimens under various levels of static compressive pre-strain up to 30%. Storage and loss moduli measured using MRE increased non-linearly with static compressive pre-strain, and exponential models fit well to these data to describe this relationship (R2>0.93). Based on these models, a 10% linear compression of liver would result in a 47% overestimate of the 'true' storage modulus of the uncompressed tissue. The results of this study have implications for MRE transducer design and interpretation of results from in vivo MRE studies.
Related Topics
Physical Sciences and Engineering Engineering Biomedical Engineering
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